Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa) Recombinant Protein | Sirpa recombinant protein

Recombinant Rat Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa)

• Gene Names: Sirpa; Bit; Ptpns1; SHPS-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa); Recombinant Rat Tyrosine-protein phosphatase non-receptor type substrate 1 (Sirpa); Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; Macrophage; Sirpa recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 32-373
• Sequence: KELKVTQAD KSVSVAAGDS ATLNCTVSSL TPVGPIKWFK GEGQNRSPIY SFIGGEHFPR ITNVSDATKR NNMDFSICIS NVTPEDAGTY YCVKFQKGIV EPDTEIKSGG GTTLYVLAKP SSPEVSGPDS RGSPGQTVNF TCKSYGFSPR NITLKWLKDG KELSHLETTI SSKSNVSYNI SSTVSVKLSP EDIHSRVICE VAHVTLEGRP LNGTANFSNI IRVSPTLKIT QQPLTPASQV NLTCQVQKFY PKALQLNWLE NGNLSRTDKP EHFTDNRDGT YNYTSLFLVN SSAHREDVVF TCQVEHDSQP AITENHTVRA FAHSSSGGSM ETIPDNNAYY NWN
• Sequence Length: 342

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 31543529
• NCBI GeneID: 25528
• NCBI Accession #: NP_037148.2
• NCBI GenBank Nucleotide #: NM_013016.2
• UniProt Accession #: P97710; O08951; O70426; Q9QWI5
• Molecular Weight: 55,691 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type substrate 1
• NCBI Official Synonym Full Names: signal-regulatory protein alpha
• NCBI Official Symbol: Sirpa
• NCBI Official Synonym Symbols: Bit; Ptpns1; SHPS-1
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type substrate 1; sirp-alpha-1; SHP substrate 1; inhibitory receptor SHPS-1; macrophage fusion receptor; signal-regulatory protein alpha-1; CD172 antigen-like family member A; macrophage membrane protein MFP150; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type substrate 1
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: Sirpa
• UniProt Synonym Gene Names: Bit; Mfr; Ptpns1; Shps1; Sirp; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1
• UniProt Entry Name: SHPS1_RAT

NCBI Description

plays a role in macrophage fusion [RGD, Feb 2006]

Uniprot Description

SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein phosphorylated amino acid binding; protein binding; SH3 domain binding

Biological Process: cell migration; cell-matrix adhesion; positive regulation of phagocytosis; actin filament organization; phagocytosis, recognition; cytoskeleton organization and biogenesis; hemopoietic progenitor cell differentiation; phagocytosis, engulfment