SIGLEC7 recombinant protein

Human SIGLEC7 Protein, His Tag

Cat. Num. AAA188833

• Gene Names: SIGLEC7; p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
• Purity: >85%; affinity purification
• Synonyms: SIGLEC7; Human SIGLEC7 Protein; His Tag; AIRM-1; AIRM1; CD328; CDw328; D-siglec; p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2; SIGLEC7 recombinant protein

• Host: HEK293 cells
• Purity/Purification: >85%; affinity purification
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization.
• Sequence: SIGLEC7 (Gln19-Leu353)+6×His tag

• Species: Human
• Tag: C-6×His tag
• Reconstitution: Reconstitute with deionized water
• Preparation and Storage: Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)

SDS-Page

(Figure 1. Human SIGLEC7 Protein, His Tag on SDS-PAGE under reducing condition.)

Related Product Information for SIGLEC7 recombinant protein

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).[UniProtKB/Swiss-Prot Function]

NCBI and Uniprot Product Information

• NCBI GI #: 25009269
• NCBI GeneID: 27036
• UniProt Accession #: Q9Y286; Q9NZQ1; Q9UJ86; Q9UJ87; Q9Y502
• Molecular Weight: 467
• NCBI Official Full Name: Sialic acid-binding Ig-like lectin 7
• NCBI Official Synonym Full Names: sialic acid binding Ig-like lectin 7
• NCBI Official Symbol: SIGLEC7
• NCBI Official Synonym Symbols: p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
• NCBI Protein Information: sialic acid-binding Ig-like lectin 7; AIRM-1; QA79 membrane protein; sialic acid binding immunoglobulin-like lectin 7; adhesion inhibitory receptor molecule 1, siglec-7
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 7
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC7
• UniProt Synonym Gene Names: AIRM1; Siglec-7; AIRM-1
• UniProt Entry Name: SIGL7_HUMAN

Uniprot Description

SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane

Molecular Function: receptor activity; carbohydrate binding

Biological Process: cell adhesion