SIGLEC6 / CD327 recombinant protein
Recombinant Human SIGLEC6 / CD327 Protein (Fc tag)
Gene Names
SIGLEC6; CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327
Purity
> 90 % as determined by SDS-PAGE
Synonyms
SIGLEC6 / CD327; Recombinant Human SIGLEC6 / CD327 Protein (Fc tag); SIGLEC6; CD33L; CD33L1; OBBP1; SIGLEC6 / CD327 recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
401
Application Notes
The recombinant human SIGLEC6/Fc is a disulfide-linked homodimer. The reduced monomer comprises 546 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of the protein is approximately 66-73 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Gln 27
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for SIGLEC6 / CD327 recombinant protein
Background: SIGLEC6, also known as CD327, belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC6 is a sialic acid recognizing protein expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. SIGLEC6 localizes in various compartments such as membrane fraction, extracellular region and so on. SIGLEC6 may show increasing expression human labor and following childbirth, it has been speculated that this expression helps to slow the tempo of human labor. Interestingly, expression of SIGLEC6 is further upregulated in pre-eclampsia, which appears to be a uniquely human disease.
Description: A DNA sequence encoding the human SIGLEC6 (O43699-3) (Gln27-Val331) was expressed with the Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the human SIGLEC6 (O43699-3) (Gln27-Val331) was expressed with the Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,348 Da
NCBI Official Full Name
sialic acid-binding Ig-like lectin 6 isoform 4
NCBI Official Synonym Full Names
sialic acid binding Ig like lectin 6
NCBI Official Symbol
SIGLEC6
NCBI Official Synonym Symbols
CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327
NCBI Protein Information
sialic acid-binding Ig-like lectin 6
UniProt Protein Name
Sialic acid-binding Ig-like lectin 6
UniProt Gene Name
SIGLEC6
UniProt Synonym Gene Names
CD33L; CD33L1; OBBP1; Siglec-6; OB-BP1
NCBI Description
This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
Uniprot Description
SIGLEC6: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: integral to plasma membrane; membrane
Molecular Function: protein binding
Biological Process: cell-cell signaling
Research Articles on SIGLEC6 / CD327
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Product Notes
The SIGLEC6 / CD327 siglec6 (Catalog #AAA2545536) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant human SIGLEC6/Fc is a disulfide-linked homodimer. The reduced monomer comprises 546 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of the protein is approximately 66-73 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the SIGLEC6 / CD327 siglec6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIGLEC6 / CD327, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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