Human serine hydroxymethyltransferase 2 (mitochondrial) ELISA Kit | SHMT2 elisa kit
Human Serine hydroxymethyltransferase, mitochondrial, SHMT2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Description
SHMT2: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Other Amino Acids Metabolism - cyanoamino acid; Energy Metabolism - methane; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Amino Acid Metabolism - glycine, serine and threonine; Methyltransferase
Chromosomal Location of Human Ortholog: 12q12-q14
Cellular Component: microtubule cytoskeleton; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; mitochondrial intermembrane space
Molecular Function: L-allo-threonine aldolase activity; identical protein binding; amino acid binding; glycine hydroxymethyltransferase activity; chromatin binding; pyridoxal phosphate binding
Biological Process: L-serine biosynthetic process; positive regulation of cell proliferation; one-carbon compound metabolic process; glycine biosynthetic process from serine; protein homotetramerization
Research Articles on SHMT2
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Product Notes
The Human SHMT2 shmt2 (Catalog #AAA9318218) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318218 ELISA Kit recognizes Human SHMT2. It is sometimes possible for the material contained within the vial of "serine hydroxymethyltransferase 2 (mitochondrial), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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