Sheep TSC22 Domain Family Protein 3 (TSC22D3) ELISA Kit | TSC22D3 elisa kit

Sheep TSC22 Domain Family Protein 3 (TSC22D3) ELISA Kit

Cat. Num. AAA9367899

• Gene Names: TSC22D3; DIP; GILZ; DSIPI; TSC-22R
• Reactivity: Sheep
• Synonyms: TSC22 Domain Family Protein 3 (TSC22D3); Sheep TSC22 Domain Family Protein 3 (TSC22D3) ELISA Kit; TSC22D3 elisa kit

• Reactivity: Sheep

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 62865625
• NCBI GeneID: 1831
• NCBI Accession #: NP_001015881.1
• NCBI GenBank Nucleotide #: NM_001015881.1
• Molecular Weight: 13,286 Da
• NCBI Official Full Name: TSC22 domain family protein 3 isoform 3
• NCBI Official Synonym Full Names: TSC22 domain family member 3
• NCBI Official Symbol: TSC22D3
• NCBI Official Synonym Symbols: DIP; GILZ; DSIPI; TSC-22R
• NCBI Protein Information: TSC22 domain family protein 3
• UniProt Protein Name: TSC22 domain family protein 3
• Protein Family: TSC22 domain family protein
• UniProt Gene Name: TSC22D3
• UniProt Synonym Gene Names: DSIPI; GILZ; Protein DIP; hDIP; GILZ; TSC-22R
• UniProt Entry Name: T22D3_HUMAN

NCBI Description

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Description

GILZ: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Belongs to the TSC-22/Dip/Bun family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq22.3

Cellular Component: cytosol; nucleus

Molecular Function: MRF binding; protein binding; transcription factor activity

Biological Process: negative regulation of skeletal muscle development; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to osmotic stress; transmembrane transport