Sheep Cholesterol 24-hydroxylase (CYP46A1) ELISA Kit | CYP46A1 elisa kit
Sheep Cholesterol 24-hydroxylase (CYP46A1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP46A1: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family.
Protein type: Membrane protein, integral; EC 1.14.13.98; Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity
Biological Process: nervous system development; bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
Research Articles on CYP46A1
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Product Notes
The Sheep CYP46A1 cyp46a1 (Catalog #AAA7248345) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7248345 ELISA Kit recognizes Sheep CYP46A1. It is sometimes possible for the material contained within the vial of "Cholesterol 24-hydroxylase (CYP46A1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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