Sex Hormone-Binding Globulin Recombinant Protein | SHBG recombinant protein

Recombinant Human Sex Hormone-Binding Globulin

Cat. Num. AAA145486

• Gene Names: SHBG; ABP; SBP; TEBG
• Synonyms: Sex Hormone-Binding Globulin; Recombinant Human Sex Hormone-Binding Globulin; SHBG Human; Sex Hormone-Binding Globulin Human Recombinant; Sex hormone-binding globulin; SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin; SHBG recombinant protein

• Host: Chinese Hamster Ovarian Cells (CHO)
• Form/Format: SHBG filtered (0.4 um) solution at a concentration of 1mg/ml in certified FBS (Fetal Bovine Serum).; Filtered colorless solution.
• Sequence: AAQPARRARR TKLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SHSRGGPEQKLISEEDLNSA VDHHHHHH.
• Sequence Length: 402

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for SHBG recombinant protein

Description: SHBG Human Recombinant produced in CHO cells is a single, glycosylated, polypeptide chain containing a total of 428 amino acids, having a molecular mass of 46.79kDa (calculated), the SHBG is fused to a 6 a.a C-terminal His tag and also includes a myc-epitope.The Human SHBG is purified by proprietary chromatographic techniques.

Introduction: Sex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen/estrogen balance, thyroid hormones, insulin and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus.

Product Categories/Family for SHBG recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 7382460
• NCBI GeneID: 6462
• NCBI Accession #: NP_001031.2
• NCBI GenBank Nucleotide #: NM_001040.4
• UniProt Accession #: P04278; P14689; Q16616; Q3MIL0; Q6ISD2; B0FWH4; E9PGW1; F5H5Z8; I3L1N7
• Molecular Weight: 41,712 Da
• NCBI Official Full Name: sex hormone-binding globulin isoform 1
• NCBI Official Synonym Full Names: sex hormone-binding globulin
• NCBI Official Symbol: SHBG
• NCBI Official Synonym Symbols: ABP; SBP; TEBG
• NCBI Protein Information: sex hormone-binding globulin; sex steroid-binding protein; testis-specific androgen-binding protein; testosterone-binding beta-globulin; testosterone-estradiol-binding globulin; testosterone-estrogen-binding globulin
• UniProt Protein Name: Sex hormone-binding globulin
• Protein Family: Sex hormone-binding globulin
• UniProt Gene Name: SHBG
• UniProt Synonym Gene Names: SHBG; SBP; ABP; TeBG
• UniProt Entry Name: SHBG_HUMAN

NCBI Description

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

SHBG: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: extracellular region

Molecular Function: androgen binding

Biological Process: primary spermatocyte growth