Mouse SH3 and multiple ankyrin repeat domains 2 ELISA Kit | SHANK2 elisa kit
Mouse SH3 and multiple ankyrin repeat domains protein 2, SHANK2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SHANK2: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Defects in SHANK2 are a cause of susceptibility to autism type 17 (AUTS17). Autism is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Belongs to the SHANK family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: neuron projection; photoreceptor inner segment; brush border membrane; postsynaptic density; dendritic spine; postsynaptic membrane; growth cone; photoreceptor outer segment; cell projection; cell soma; membrane; apical plasma membrane; cytoplasm; presynaptic active zone; neurofilament; plasma membrane; ionotropic glutamate receptor complex; synapse; cell junction
Molecular Function: protein C-terminus binding; ionotropic glutamate receptor binding; SH3 domain binding
Biological Process: synaptogenesis; adult behavior; learning; social behavior; memory
Research Articles on SHANK2
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Product Notes
The Mouse SHANK2 shank2 (Catalog #AAA9343375) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343375 ELISA Kit recognizes Mouse SHANK2. It is sometimes possible for the material contained within the vial of "SH3 and multiple ankyrin repeat domains 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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