SH3 domain-binding protein 4 (SH3BP4) Recombinant Protein | SH3BP4 recombinant protein

Recombinant Human SH3 domain-binding protein 4 (SH3BP4) , partial

• Gene Names: SH3BP4; TTP; BOG25
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: SH3 domain-binding protein 4 (SH3BP4); Recombinant Human SH3 domain-binding protein 4 (SH3BP4); partial; SH3BP4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 552

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SH3BP4 recombinant protein

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.

NCBI and Uniprot Product Information

• NCBI GI #: 7657562
• NCBI GeneID: 23677
• NCBI Accession #: NP_055336.1
• NCBI GenBank Nucleotide #: NM_014521.2
• UniProt Accession #: Q9P0V3; O95082; Q309A3; Q53QD0; Q53TD1
• Molecular Weight: 60,337 Da
• NCBI Official Full Name: SH3 domain-binding protein 4
• NCBI Official Synonym Full Names: SH3 domain binding protein 4
• NCBI Official Symbol: SH3BP4
• NCBI Official Synonym Symbols: TTP; BOG25
• NCBI Protein Information: SH3 domain-binding protein 4
• UniProt Protein Name: SH3 domain-binding protein 4
• Protein Family: SH3 domain-binding protein
• UniProt Gene Name: SH3BP4
• UniProt Synonym Gene Names: BOG25; EHB10; TTP

NCBI Description

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.