Mouse SH2B adaptor protein 2 ELISA Kit | SH2B2 elisa kit

Mouse SH2B adapter protein 2, SH2B2 ELISA Kit

Cat. Num. AAA9324123

• Gene Names: Sh2b2; Aps
• Reactivity: Mouse
• Synonyms: SH2B adaptor protein 2; Mouse SH2B adapter protein 2; SH2B2 ELISA Kit; Mouse SH2B adapter protein 2 (SH2B2) ELISA kit; APS; SH2 and PH domain-containing adapter protein APS; adaptor protein with pleckstrin homology and src homology 2 domains; SH2B2 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 40254556
• NCBI GeneID: 23921
• NCBI Accession #: NP_061295.2
• NCBI GenBank Nucleotide #: NM_018825.3
• UniProt Accession #: Q9JID9; O88936; Q6PG00
• Molecular Weight: 66,557 Da
• NCBI Official Full Name: SH2B adapter protein 2
• NCBI Official Synonym Full Names: SH2B adaptor protein 2
• NCBI Official Symbol: Sh2b2
• NCBI Official Synonym Symbols: Aps
• NCBI Protein Information: SH2B adapter protein 2; insulin receptor substrate 5; SH2 and PH domain-containing adapter protein APS; adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains
• UniProt Protein Name: SH2B adapter protein 2
• Protein Family: SH2B adapter protein
• UniProt Gene Name: Sh2b2
• UniProt Synonym Gene Names: Aps
• UniProt Entry Name: SH2B2_MOUSE

Uniprot Description

APS: an adapter protein involved in coupling immunoreceptors to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. Interacts with several proteins including KIT/c-KIT, SHC, GRB2, EPOR, CBL/c-CBL, PDGFR, VAV1 and VAV3. Interacts with SHC through its N-terminal region, with GRB2 via the phosphorylated C-terminus and with EPOR and KIT via its SH2 domain. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts with VAV3 via its PH domain, inducing cytoskeletal reorganization. Expressed in spleen, prostrate, testis, uterus, small intestine and skeletal muscle. Among haematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex.

Protein type: Adaptor/scaffold

Cellular Component: ruffle; membrane; cytoplasm; stress fiber; plasma membrane; actin filament

Molecular Function: identical protein binding; signal transducer activity; protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; JAK pathway signal transduction adaptor activity

Biological Process: regulation of Ras protein signal transduction; antigen receptor-mediated signaling pathway; nervous system development; regulation of immune response; positive regulation of signal transduction; cytokine and chemokine mediated signaling pathway; B-1 B cell homeostasis; glucose homeostasis; negative regulation of glucose import; regulation of JAK-STAT cascade; insulin receptor signaling pathway; brown fat cell differentiation; regulation of metabolic process; actin cytoskeleton organization and biogenesis