SGTA recombinant protein

Recombinant Human SGTA Protein (N-6His)

Cat. Num. AAA2553230

• Gene Names: SGTA; SGT; hSGT; alphaSGT
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: SGTA; Recombinant Human SGTA Protein (N-6His); Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha; Alpha-SGT; Vpu-Binding Protein; UBP; SGT; SGT1; SGTA recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
• Sequence Positions: Met1-Glu313
• Sequence Length: 313

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for SGTA recombinant protein

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein alpha (SGTA) is an ubiquitously expressed protein which belongs to the SGT Family. SGTA contains three TPR Protein-Protein Interaction Duplicates. SGTA is a co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. SGTA is capable of interacting with the major nonstructural protein of Parvovirus H-1 and 70-kDa heat shock cognate protein. It interacts with NS1 from Parvovirus H-1, with Vpu and Gag from HIV-1. It also interacts with SARS-CoV Accessory Protein 7a, DNAJC5 and DNAJC5B. However, its function is not known. Since this transcript is expressed ubiquitously in various tissues, SGTA may serve a housekeeping function.

NCBI and Uniprot Product Information

• NCBI GI #: 4506921
• NCBI GeneID: 6449
• NCBI Accession #: NP_003012.1
• NCBI GenBank Nucleotide #: NM_003021.3
• UniProt Accession #: O43765; Q6FIA9; Q9BTZ9; D6W610
• Molecular Weight: Molecular Mass: 36.2 kDa; Actual Protein Molecular Mass: 35 kDa
• NCBI Official Full Name: small glutamine-rich tetratricopeptide repeat-containing protein alpha
• NCBI Official Synonym Full Names: small glutamine rich tetratricopeptide repeat containing alpha
• NCBI Official Symbol: SGTA
• NCBI Official Synonym Symbols: SGT; hSGT; alphaSGT
• NCBI Protein Information: small glutamine-rich tetratricopeptide repeat-containing protein alpha
• UniProt Protein Name: Small glutamine-rich tetratricopeptide repeat-containing protein alpha
• Protein Family: Small glutamine-rich tetratricopeptide repeat-containing protein
• UniProt Gene Name: SGTA
• UniProt Synonym Gene Names: SGT; SGT1; UBP

NCBI Description

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

Uniprot Description

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).