SGK2 / Serine/Threonine-Protein Kinase Sgk2 Recombinant Protein | SGK2 recombinant protein

Human SGK2 / Serine/Threonine-Protein Kinase Sgk2 Recombinant Protein

• Gene Names: SGK2; H-SGK2; dJ138B7.2
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: SGK2 / Serine/Threonine-Protein Kinase Sgk2; Human SGK2 / Serine/Threonine-Protein Kinase Sgk2 Recombinant Protein; Serine/threonine-protein kinase Sgk2; Serum/glucocorticoid-regulated kinase 2; SGK2 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 427

• Applicable Applications for SGK2 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Entry Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 20127541
• NCBI GeneID: 10110
• NCBI Accession #: NP_057360.2
• NCBI GenBank Nucleotide #: NP_057360.2
• UniProt Accession #: Q9HBY8
• NCBI Official Full Name: serine/threonine-protein kinase Sgk2 isoform beta
• NCBI Official Synonym Full Names: serum/glucocorticoid regulated kinase 2
• NCBI Official Symbol: SGK2
• NCBI Official Synonym Symbols: H-SGK2; dJ138B7.2
• NCBI Protein Information: serine/threonine-protein kinase Sgk2
• UniProt Protein Name: Serine/threonine-protein kinase Sgk2
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: SGK2
• UniProt Entry Name: SGK2_HUMAN

NCBI Description

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Uniprot Description

SGK2: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; SGK family

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; potassium channel regulator activity; sodium channel regulator activity; ATP binding

Biological Process: positive regulation of transporter activity; regulation of cell growth; response to oxidative stress; transmembrane transport; protein amino acid phosphorylation; regulation of cell proliferation