Phosphoinositide 3-kinase p110g Active Protein | PI3KgHis active protein
Recombinant Human Phosphoinositide 3-kinase p110g
Gene Names
PIK3C2B; C2-PI3K
Purity
Greater than 95.0% as determined by SDS-PAGE.
Synonyms
Phosphoinositide 3-kinase p110g; Recombinant Human Phosphoinositide 3-kinase p110g; PI3KgHis Human; Phosphoinositide 3-kinase p110g Human Recombinant; PI3Kg; PI3KgHis active protein
Host
Sf9 Insect Cells
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
Protein solution (1mg/ml) in 25mM Tris-HCl, pH 8.0, 50mM NaCl, 0.5mM MgCl2 and 50% glycerol.
Sterile Filtered clear solution.
Sterile Filtered clear solution.
Sequence
KAQVNPAICR YPLGMSGGQI PDEDITASSQ WSESTAAKYG RLDSEEGDGA WCPEIPVEPD DLKEFLQIDL HTLHFITLVG TQGRHAGGHG IEFAPMYKIN YSRDGTRWIS WRNRHGKQVL DGNSNPYDIF LKDLEPPIVA RFVRFIPVTD HSMNVCMRVE LYGCVWLDGL VSYNAPAGQQ FVLPGGSIIY LNDSVYDGAV GYSMTEGLGQ LTDGVSGLDD FTQTHEYHVW PGYDYVGWRN ESATNGYIEI MFEFDRIRNF TTMKVHCNNM FAKGVKIFKE VQCYFRSEAS EWEPNAISFP LVLDDVNPSA RFVTVPLHHR MASAIKCQYH FADTWMMFSE ITFQSDAAMY NNSEALPTSP MAPTTYDPML KVDDSNTRLE HHHHHH
Sequence Length
1634
Biological Activity
~ 4.5 nmol/mg/min using phosphatidylinositol as the substrate.
Preparation and Storage
PI3Kg although stable at 14 degree C for 1 week, should be stored below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Related Product Information for PI3KgHis active protein
Description: Recombinant full length PI3Kg (126.3 kDa without Tag) carries an N-terminal His 8 affinity Tag.
Introduction: PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8a-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kg.
Introduction: PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8a-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kg.
Product Categories/Family for PI3KgHis active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
184,768 Da
NCBI Official Full Name
phosphoinositide 3-kinase
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
NCBI Official Symbol
PIK3C2B
NCBI Official Synonym Symbols
C2-PI3K
NCBI Protein Information
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; PI3K-C2-beta; PI3K-C2beta; PTDINS-3-kinase C2 beta; phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; phosphoinositide 3-kinase-C2-beta; phosphoinositide-3-kinase, class 2, beta polypeptide; ptdIns-3-kinase C2 subunit beta
UniProt Protein Name
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
UniProt Gene Name
PIK3C2B
UniProt Synonym Gene Names
PI3K-C2-beta; PtdIns-3-kinase C2 subunit beta
UniProt Entry Name
P3C2B_HUMAN
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Product Notes
The PI3KgHis pik3c2b (Catalog #AAA142823) is an Active Protein produced from Sf9 Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: KAQVNPAICR YPLGMSGGQI PDEDITASSQ WSESTAAKYG RLDSEEGDGA WCPEIPVEPD DLKEFLQIDL HTLHFITLVG TQGRHAGGHG IEFAPMYKIN YSRDGTRWIS WRNRHGKQVL DGNSNPYDIF LKDLEPPIVA RFVRFIPVTD HSMNVCMRVE LYGCVWLDGL VSYNAPAGQQ FVLPGGSIIY LNDSVYDGAV GYSMTEGLGQ LTDGVSGLDD FTQTHEYHVW PGYDYVGWRN ESATNGYIEI MFEFDRIRNF TTMKVHCNNM FAKGVKIFKE VQCYFRSEAS EWEPNAISFP LVLDDVNPSA RFVTVPLHHR MASAIKCQYH FADTWMMFSE ITFQSDAAMY NNSEALPTSP MAPTTYDPML KVDDSNTRLE HHHHHH. It is sometimes possible for the material contained within the vial of "Phosphoinositide 3-kinase p110g, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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