NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
Uniprot Description
SESN2: Involved in the reduction of peroxiredoxins. Widely expressed. Belongs to the sestrin family.
Protein type: Enzyme, misc.
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus
Molecular Function: protein binding
Biological Process: autophagy; fatty acid beta-oxidation; gene expression; glucose import; mitochondrial DNA metabolic process; protein kinase B signaling cascade; response to glucose stimulus; response to insulin stimulus; transcription initiation from RNA polymerase II promoter