Plasminogen Activator Inhibitor 1/PAI-1/SERPIN E1 Recombinant Protein | PAI-1 recombinant protein

Recombinant Mouse Plasminogen Activator Inhibitor 1/PAI-1/SERPIN E1 Protein (C-6His)

Cat. Num. AAA2553594

• Gene Names: Serpine1; PAI1; PAI-1; Planh1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Plasminogen Activator Inhibitor 1/PAI-1/SERPIN E1; Recombinant Mouse Plasminogen Activator Inhibitor 1/PAI-1/SERPIN E1 Protein (C-6His); Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; Serpin E1; Mr1; Pai1; Planh1; PAI-1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Leu24-Ser402
• Sequence Length: 402

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for PAI-1 recombinant protein

Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

NCBI and Uniprot Product Information

• NCBI GI #: 129577
• NCBI GeneID: 18787
• UniProt Accession #: P22777
• Molecular Weight: Molecular Mass: 43.7 kDa; Actual Protein Molecular Mass: 50kDa
• NCBI Official Full Name: Plasminogen activator inhibitor 1
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade E, member 1
• NCBI Official Symbol: Serpine1
• NCBI Official Synonym Symbols: PAI1; PAI-1; Planh1
• NCBI Protein Information: plasminogen activator inhibitor 1
• UniProt Protein Name: Plasminogen activator inhibitor 1
• UniProt Gene Name: Serpine1
• UniProt Synonym Gene Names: Mr1; Pai1; Planh1; PAI; PAI-1

Uniprot Description

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis ().