SerpinB6 recombinant protein

SerpinB6 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121228

• Purity: >90% as determined by SDS-PAGE
• Synonyms: SerpinB6; SerpinB6 Protein; Human; Recombinant (His Tag); Human SerpinB6/PI-6 Protein (His Tag); CAP Protein; DFNB91 Protein; DKFZp686I04222 Protein; MGC111370 Protein; MSTP057 Protein; PI-6 Protein; PI6 Protein; PTI Protein; RP1-90J20.6 Protein; Serpin B6 Protein; SPI3 Protein; serpin peptidase inhibitor; clade B (ovalbumin); member 6; SerpinB6 recombinant protein

• Host: Baculovirus-Insect Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Asp2-Pro376

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Met
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human SERPINB6 (AAB30320.1)(Asp 2-Pro 376) was expressed, with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for SerpinB6 recombinant protein

Background: SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6/PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6/PI-6 is expressed in keratinocytes (at protein level). It is also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. SerpinB6/PI-6 is expressed in the inner ear hair cells. It's expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. SerpinB6/PI-6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Defects in SerpinB6 are the cause of deafness autosomal recessive type 91 which is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.

References

Morgenstern KA. et al.,1994, Biochemistry. 33: 3432-41. Strik MC. et al., 2004, Blood. 103: 2710-7. Scott FL. et al., 2007, J Biochem. 142: 435-42. Burkard TR. et al., 2011, BMC Syst Biol. 5:17.

NCBI and Uniprot Product Information

• NCBI GI #: 546088
• Molecular Weight: 42,622 Da
• NCBI Official Full Name: cytoplasmic antiproteinase
• Protein Family: Serpin