Presenilin sel-12 (sel-12) Recombinant Protein | sel-12 recombinant protein
Recombinant Caenorhabditis elegans Presenilin sel-12 (sel-12), partial
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Presenilin sel-12 (sel-12); Recombinant Caenorhabditis elegans Presenilin sel-12 (sel-12); partial; sel-12 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-444
Sequence
MPSTRRQQEGGGADAETHTVYGTNLITNRNSQEDENVVEEAELKYGASHVIHLFVPVSLCMALVVFTMNTITFYSQNNGRHLLYTPFVRETDSIVEKGLMSLGNALVMLCVVVLMTVLLIVFYKYKFYKLIHGWLIVSSFLLLFLFTTIYVQEVLKSFDVSPSALLVLFGLGNYGVLGMMCIHWKGPLRLQQFYLITMSALMALVFIKYLPEWTVWFVLFVISVWDLVAVLTPKGPLRYLVETAQERNEPIFPALIYSSGVIYPYVLVTAVENTTDPREPTSSDSNTSTAFPGEASCSSETPKRPKVKRIPQKVQIESNTTASTTQNSGVRVERELAAERPTVQDANFHRHEEEERGVKLGLGDFIFYSVLLGKASSYFDWNTTIACYVAILIGLCFTLVLLAVFKRALPALPISIFSGLIFYFCTRWIITPFVTQVSQKCLLY
Sequence Length
444
Species
Caenorhabditis elegans
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
50,034 Da
NCBI Official Full Name
Presenilin sel-12
NCBI Official Symbol
sel-12
NCBI Protein Information
Presenilin sel-12
UniProt Protein Name
Presenilin sel-12
Protein Family
UniProt Gene Name
sel-12
Uniprot Description
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function.
Research Articles on sel-12
1. mutations in sel-12 result in defects in calcium homeostasis, leading to mitochondrial dysfunction
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Product Notes
The sel-12 sel-12 (Catalog #AAA1029147) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-444. The amino acid sequence is listed below: MPSTRRQQEG GGADAETHTV YGTNLITNRN SQEDENVVEE AELKYGASHV IHLFVPVSLC MALVVFTMNT ITFYSQNNGR HLLYTPFVRE TDSIVEKGLM SLGNALVMLC VVVLMTVLLI VFYKYKFYKL IHGWLIVSSF LLLFLFTTIY VQEVLKSFDV SPSALLVLFG LGNYGVLGMM CIHWKGPLRL QQFYLITMSA LMALVFIKYL PEWTVWFVLF VISVWDLVAV LTPKGPLRYL VETAQERNEP IFPALIYSSG VIYPYVLVTA VENTTDPREP TSSDSNTSTA FPGEASCSSE TPKRPKVKRI PQKVQIESNT TASTTQNSGV RVERELAAER PTVQDANFHR HEEEERGVKL GLGDFIFYSV LLGKASSYFD WNTTIACYVA ILIGLCFTLV LLAVFKRALP ALPISIFSGL IFYFCTRWII TPFVTQVSQK CLLY. It is sometimes possible for the material contained within the vial of "Presenilin sel-12 (sel-12), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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