E3 ubiquitin-protein ligase hrd-1 (sel-11) Recombinant Protein | sel-11 recombinant protein
Recombinant E3 ubiquitin-protein ligase hrd-1 (sel-11)
NCBI and Uniprot Product Information
Uniprot Description
Function: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation
By similarity. UniProtKB Q20798
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Homodimer
By similarity. UniProtKB Q86TM6
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
By similarity UniProtKB Q86TM6.
Domain: The RING-type zinc finger is required for E3 ligase activity
By similarity. UniProtKB Q86TM6
Sequence similarities: Belongs to the HRD1 family.Contains 1 RING-type zinc finger.
Similar Products
Product Notes
The E3 ubiquitin-protein ligase hrd-1 (sel-11) sel-11 (Catalog #AAA1120498) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-622. The amino acid sequence is listed below: FVINKQFYPS IVYLSKSNAS MAVLYFQGIV LVYLMFQLLK SILFGDLRAA EAEHLSERTW HAVLETCLAF TVFRDDFSAM FVMQFIGLLF IKCFHWLADD RVDMMERSPV ITLRFHLRMM TVLAALGFAD SYFVSSAYFS TITKGASSQI VFGFEYAILL ALVLHVTIKY LLHMHDLRNP QSWDNKAVYL LYAELLINLI RCVLYGFFAV IMLRVHTFPL FSVRPFYQSV RALHKAFLDV ILSRRAINAM NSQFPVVSND ELSAMDATCI ICREEMTVES SPKRLPCSHV FHAHCLRSWF QRQQTCPTCR TDIWQGRNGA AGGANAGGAA ENNAAGAPPA AGIPPFLPFL GHQFGFPQAA AGAQVGGAQA GGHPGPFPHQ IFYAPAPANR PEFMNLAPPP MPMAGPPGMF PMMPPPPIPQ PNAAPGESSN AEPPGRPNFD RFSVEELHRM EGDMRDAILA RIQAMENIMV ILESAQVQMV QLAAITPLRR PVPTAEASEE ETATASSVPT SVPSEEPSPA PSTPETASAP RSMFRGNLFN DTQSTSTPST SAGPQPSLTP STSSVPSTSS VRTPEADEVR QRRLAHLNAR FPPPNPEHE. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase hrd-1 (sel-11), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
