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2 results for "Acid pump antagonist" - showing 1-2
Testing Data
(PF-03716556 is a potent, and selective acid pump antagonist with pIC50 of 6.026 +/- 0.112, 6.038 +/- 0.039 and 6.009 +/- 0.209 at pH 6.4 for the inhibition of H+, K+-ATPase activity of porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 is used for the treatment of gastroesophageal reflux disease. PF-03716556 is highly selective for H+, K+-ATPase in vitro. PF-03716556 displays no activity at Na+, K+-ATPase. PF-03716556 inhibits gastric acid secretion in rat and dog models. PF-03716556 has no species differences among the porcine, canine and human enzymes. PF-03716556 produced greater inhibition than revaprazan in both the in vitro (ion-tight assay) and in vivo conditions. PF-03716556 offers long-lasting and maximal efficacy within 30 min of a single dosing with responses that are maintained for at least 5 days of repeated dosing with no signs of tolerance. PF-03716556 did not exhibit any biologically relevant activity against any of the tested more than 50 (e.g., adenosine receptor) receptors, ion channels, or enzymes expressed in na¯ve tissues, cell lines and transfectants. [1])
PF 3716556, Inhibitor (Cat# AAA8506512)
Full Name
PF 3716556
Purity
>99%
Pricing
$410/10 mg | $1,795/5x10 mg
Chemical Structure
Revaprazan Hydrochloride, Antagonist (Cat# AAA3842370)
Full Name
Revaprazan Hydrochloride
Purity
>98%
Pricing
$130/10 mg | $230/50 mg | $340/100 mg | $1,465/5x100 mg
