Syntenin Recombinant Protein | SDCBP recombinant protein

Syntenin Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121921

• Gene Names: SDCBP; ST1; MDA9; SYCL; MDA-9; TACIP18
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Syntenin; Syntenin Protein; Human; Recombinant (His Tag); Human Syntenin-1 Protein (His Tag); MDA-9 Protein; MDA9 Protein; ST1 Protein; SYCL Protein; TACIP18 Protein; syndecan binding protein (syntenin); SDCBP recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Val298

• Species: Human
• Predicted N Terminal: Met
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human SDCBP (NP_001007068.1)(Met1-Val298) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for SDCBP recombinant protein

Background: Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy.

NCBI and Uniprot Product Information

• NCBI GI #: 55749490
• NCBI GeneID: 6386
• NCBI Accession #: NP_001007068.1
• NCBI GenBank Nucleotide #: NM_001007067.1
• UniProt Accession #: O00560; O00173; O43391; Q14CP2; B2R5Q7; B4DUH3; B7ZLN2
• Molecular Weight: 31,762 Da
• NCBI Official Full Name: syntenin-1 isoform 1
• NCBI Official Synonym Full Names: syndecan binding protein (syntenin)
• NCBI Official Symbol: SDCBP
• NCBI Official Synonym Symbols: ST1; MDA9; SYCL; MDA-9; TACIP18
• NCBI Protein Information: syntenin-1; melanoma differentiation associated protein-9; melanoma differentiation-associated protein 9; pro-TGF-alpha cytoplasmic domain-interacting protein 18; scaffold protein Pbp1; syndecan-binding protein 1
• UniProt Protein Name: Syntenin-1
• Protein Family: Syntenin
• UniProt Gene Name: SDCBP
• UniProt Synonym Gene Names: MDA9; SYCL; MDA-9; TACIP18
• UniProt Entry Name: SDCB1_HUMAN

NCBI Description

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Adaptor/scaffold; Vesicle; Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 8q12

Cellular Component: extracellular space; endoplasmic reticulum membrane; focal adhesion; cytosol; adherens junction; cytoskeleton; membrane; cytoplasm; plasma membrane; melanosome; interleukin-5 receptor complex; nucleus; vesicle

Molecular Function: syndecan binding; protein C-terminus binding; identical protein binding; protein homodimerization activity; ephrin receptor binding; protein N-terminus binding; protein binding; interleukin-5 receptor binding; protein heterodimerization activity; frizzled binding; neurexin binding; growth factor binding; cytoskeletal adaptor activity; cell adhesion molecule binding; glycoprotein binding

Biological Process: synaptic transmission; axon guidance; Ras protein signal transduction; ephrin receptor signaling pathway; positive regulation of JNK cascade; actin cytoskeleton organization and biogenesis; protein targeting to membrane; substrate-bound cell migration, cell extension; positive regulation of phosphorylation