Lysosome membrane protein 2 (Scarb2) Recombinant Protein | Scarb2 recombinant protein

Recombinant Mouse Lysosome membrane protein 2 (Scarb2)

• Gene Names: Scarb2; LGP85; Cd36l2; LIMP-2; MLGP85; 9330185J12Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lysosome membrane protein 2 (Scarb2); Recombinant Mouse Lysosome membrane protein 2 (Scarb2); Recombinant Lysosome membrane protein 2 (Scarb2); Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; LGP85 Lysosome membrane protein II; LIMP II Scavenger receptor class B member 2; Scarb2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-478
• Sequence: GRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEILQGEIPLLEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPLLTVVDLAQLTLLRELIEAMLKAYQQKLFVIHTVHELLWGYKDEILSLVHIFKPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILANTSENAGFCIPEGNCMDSGVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINPLTGIILRGAKRFQINTYVRKLDDFVETGDIRTMVFPVMYLNESVLIDKETANQLKSVINTTLVVTNIPYIIMALGVFFGLVFTWLACRGQGSMDEGTADERAPLIRT
• Sequence Length: 478

• Species: Mus musculus (Mouse)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 6680878
• NCBI GeneID: 12492
• NCBI Accession #: NP_031670.1
• NCBI GenBank Nucleotide #: NM_007644.3
• UniProt Accession #: O35114; Q3UNF8
• Molecular Weight: 54,044 Da
• NCBI Official Full Name: lysosome membrane protein 2
• NCBI Official Synonym Full Names: scavenger receptor class B, member 2
• NCBI Official Symbol: Scarb2
• NCBI Official Synonym Symbols: LGP85; Cd36l2; LIMP-2; MLGP85; 9330185J12Rik
• NCBI Protein Information: lysosome membrane protein 2; LIMP II; lysosome membrane protein II; 85 kDa lysosomal membrane sialoglycoprotein; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2
• UniProt Protein Name: Lysosome membrane protein 2
• Protein Family: Lysosome membrane protein
• UniProt Gene Name: Scarb2
• UniProt Synonym Gene Names: LGP85; LIMP II
• UniProt Entry Name: SCRB2_MOUSE

NCBI Description

This gene encodes a CD36-like type III transmembrane glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015]

Uniprot Description

SCARB2: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4). An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Cellular Component: lysosomal lumen; focal adhesion; membrane; cell; lysosomal membrane; lysosome; integral to membrane; intracellular

Molecular Function: enzyme binding; receptor activity

Biological Process: protein targeting to lysosome; cell adhesion