SAA4 recombinant protein

SAA4 Protein, Human, Recombinant (GST Tag)

Cat. Num. AAA8120786

• Gene Names: SAA4; CSAA; C-SAA
• Purity: >93% as determined by SDS-PAGE
• Synonyms: SAA4; SAA4 Protein; Human; Recombinant (GST Tag); Human SAA4 Protein (GST Tag); C-SAA Protein; CSAA Protein; serum amyloid A4; constitutive; SAA4 recombinant protein

• Host: E Coli
• Purity/Purification: >93% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, 0.5% Triton X-100, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Glu19-Tyr130

• Species: Human
• Predicted N Terminal: Met
• Tag: N-GST
• Protein Construction: A DNA sequence encoding the mature form of human SAA4 (P35542)(Glu19-Tyr130) was fused with the GST tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for SAA4 recombinant protein

Background: SAA4 is a member of the SAA family. SAA proteins are family of apolipoproteins of high density lipoprotein (HDL). They can be separated into two distinct groups. First group (SAA1, SAA2, and SAA3) consists of acute phase reactant whose expression level increase in the blood in a response to trauma, infection, inflammation, and neoplasia. These acute phase SAAs associates with HDL during inflammation and remodel the HDL particle by displacing Apo-A1. The second distinct group consists of SAA4 and SAA5 which exist as the minor apolipoproteins on HDL, but this group of SAA constitutes more than 90% of all the SAA during homeostasis, and it is thought to play a role in the normal functioning of the HDL particle. SAA4 is a constitutively expressed protein which expressed only in humans and mice. It is connected almost completely with lipoproteins of the high density range. The physiological function of SAA4 is unknown, and its serum concentration has no association with those of other major apolipoproteins.

References

Davila S, et al. (2010) New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun. 11(3):232-8.Murphy CL, et al. (2009) AA amyloidosis associated with a mutated serum amyloid A4 protein. Mol Med. Amyloid. 16(2):84-8.Prakash T, et al. (2010) Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. PLoS One. 5(10):e13284.

NCBI and Uniprot Product Information

• NCBI GI #: 315075333
• NCBI GeneID: 6291
• NCBI Accession #: NP_006503.2
• NCBI GenBank Nucleotide #: NM_006512.3
• UniProt Accession #: P35542; Q6FHJ4
• Molecular Weight: 14,747 Da
• NCBI Official Full Name: serum amyloid A-4 protein
• NCBI Official Synonym Full Names: serum amyloid A4, constitutive
• NCBI Official Symbol: SAA4
• NCBI Official Synonym Symbols: CSAA; C-SAA
• NCBI Protein Information: serum amyloid A-4 protein; constitutively expressed serum amyloid A protein
• UniProt Protein Name: Serum amyloid A-4 protein
• Protein Family: Serum amyloid A-4 protein
• UniProt Gene Name: SAA4
• UniProt Synonym Gene Names: CSAA; C-SAA
• UniProt Entry Name: SAA4_HUMAN

Uniprot Description

SAA4: Major acute phase reactant. Apolipoprotein of the HDL complex. Belongs to the SAA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.1-p14

Cellular Component: extracellular region

Biological Process: acute-phase response