S100A11 recombinant protein

S100A11 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122621

• Gene Names: S100a11; cal; EMAPI; Emap1; S100c; S100a14
• Purity: >90% as determined by SDS-PAGE
• Synonyms: S100A11; S100A11 Protein; Mouse; Recombinant (His Tag); Mouse S100A11/S100C Protein (His Tag); cal Protein; Emap1 Protein; EMAPI Protein; S100a14 Protein; S100c Protein; S100 calcium binding protein A11; S100A11 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, 10% glycerol, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ile98

• Species: Mouse
• Predicted N Terminal: Met
• Tag: N-His
• Protein Construction: A DNA sequence encoding the mouse S100A11 (NP_058020.1)(Met1-Ile98) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for S100A11 recombinant protein

Background: Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferation of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel test marker in breast carcinoma.

Product Categories/Family for S100A11 recombinant protein

Calcium-binding Proteins and Related Molecules

References

Miyasaki KT. et al., 1993, J Dent Res. 72: 517-23. Ohuchida K. et al., 2006, Clin Cancer Res 12 (18): 5417-22. Kouno T. et al., 2008, J Pept Sci. 14 (10): 1129-38. He H. et al., 2009, Cell Biochem Biophys 55 (3): 117-26. Liu XG. et al., 2010, Oncol Rep. 23 (5): 1301-8.

NCBI and Uniprot Product Information

• NCBI GI #: 21886811
• NCBI GeneID: 20195
• NCBI Accession #: NP_058020.1
• NCBI GenBank Nucleotide #: NM_016740.3
• UniProt Accession #: P50543; Q545S1
• Molecular Weight: 11,083 Da
• NCBI Official Full Name: protein S100-A11
• NCBI Official Synonym Full Names: S100 calcium binding protein A11
• NCBI Official Symbol: S100a11
• NCBI Official Synonym Symbols: cal; EMAPI; Emap1; S100c; S100a14
• NCBI Protein Information: protein S100-A11
• UniProt Protein Name: Protein S100-A11
• Protein Family: Protein
• UniProt Gene Name: S100a11
• UniProt Synonym Gene Names: S100c; EMAP

Uniprot Description

Facilitates the differentiation and the cornification of keratinocytes.