Cat Soluble Retinoid X Receptor ELISA Kit | RXR elisa kit

Cat Soluble Retinoid X Receptor ELISA Kit

• Gene Names: Srebf1; ADD1; ADD-1; SREBP1; bHLHd1; SREBP-1; SREBP1c; SREBP-1a; SREBP-1c; D630008H06
• Reactivity: Cat
• Synonyms: Soluble Retinoid X Receptor; Cat Soluble Retinoid X Receptor ELISA Kit; RXR elisa kit

• Reactivity: Cat
• Sequence Length: 1134

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 158524238
• NCBI GeneID: 20787
• UniProt Accession #: Q9WTN3; Q3U458; Q3UDJ3; Q5SRX5; Q8C733; Q99JK7
• Molecular Weight: 120,537 Da
• NCBI Official Full Name: Sterol regulatory element-binding protein 1
• NCBI Official Synonym Full Names: sterol regulatory element binding transcription factor 1
• NCBI Official Symbol: Srebf1
• NCBI Official Synonym Symbols: ADD1; ADD-1; SREBP1; bHLHd1; SREBP-1; SREBP1c; SREBP-1a; SREBP-1c; D630008H06
• NCBI Protein Information: sterol regulatory element-binding protein 1; adipocyte determination- and differentiation-dependent factor 1
• UniProt Protein Name: Sterol regulatory element-binding protein 1
• Protein Family: Retinoic acid receptor
• UniProt Gene Name: Srebf1
• UniProt Synonym Gene Names: Srebp1; SREBP-1
• UniProt Entry Name: SRBP1_MOUSE

Uniprot Description

SREBP-1: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Membrane protein, multi-pass; Transcription factor; Membrane protein, integral

Cellular Component: Golgi apparatus; protein complex; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; cytoplasm; integral to membrane; cytoplasmic vesicle; nucleus

Molecular Function: protein dimerization activity; protein binding; sterol response element binding; DNA binding; sequence-specific DNA binding; protein complex binding; chromatin binding; transcription factor activity; protein kinase binding

Biological Process: steroid metabolic process; cholesterol metabolic process; positive regulation of fatty acid biosynthetic process; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; lipid biosynthetic process; positive regulation of cholesterol biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; negative regulation of insulin secretion; positive regulation of histone deacetylation; regulation of transcription, DNA-dependent; chemical signal regulation of heart rate; regulation of fatty acid metabolic process; insulin receptor signaling pathway; response to glucose stimulus; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; regulation of insulin secretion