Rotatin (RTTN) Recombinant Protein | RTTN recombinant protein

Recombinant Human Rotatin (RTTN) , partial

• Gene Names: RTTN; MSSP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Rotatin (RTTN); Recombinant Human Rotatin (RTTN); partial; RTTN recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 879

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 972781967
• NCBI GeneID: 25914
• NCBI Accession #: NP_001305449.1
• NCBI GenBank Nucleotide #: NM_001318520.1
• UniProt Accession #: Q86VV8; Q68CS9; Q6ZRL8; Q6ZTK3; Q86TG4; Q8N8N8; Q8TBQ4; Q96IN9; Q9UFJ4
• Molecular Weight: 98,936 Da
• NCBI Official Full Name: rotatin isoform 2
• NCBI Official Synonym Full Names: rotatin
• NCBI Official Symbol: RTTN
• NCBI Official Synonym Symbols: MSSP
• NCBI Protein Information: rotatin
• UniProt Protein Name: Rotatin
• Protein Family: Rotatin
• UniProt Gene Name: RTTN

NCBI Description

This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]

Uniprot Description

Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.