Reticulon-2 (RTN2) Recombinant Protein | RTN2 recombinant protein

Recombinant Human Reticulon-2 (RTN2)

• Gene Names: RTN2; NSP2; NSPL1; NSPLI; SPG12
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Reticulon-2 (RTN2); Recombinant Human Reticulon-2 (RTN2); Recombinant Reticulon-2 (RTN2); Reticulon-2; Neuroendocrine-specific protein-like 1; NSP-like protein 1 Neuroendocrine-specific protein-like I; NSP-like protein I; NSPLI; RTN2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-545
• Sequence: MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLWTAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
• Sequence Length: 545

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 5032055
• NCBI GeneID: 6253
• NCBI Accession #: NP_005610.1
• NCBI GenBank Nucleotide #: NM_005619.4
• UniProt Accession #: O75298; O60509; Q7RTM6; Q7RTN1; Q7RTN2
• Molecular Weight: 59,264 Da
• NCBI Official Full Name: reticulon-2 isoform A
• NCBI Official Synonym Full Names: reticulon 2
• NCBI Official Symbol: RTN2
• NCBI Official Synonym Symbols: NSP2; NSPL1; NSPLI; SPG12
• NCBI Protein Information: reticulon-2; NSP-like protein 1; NSP-like protein I; neuroendocrine-specific protein-like I
• UniProt Protein Name: Reticulon-2
• Protein Family: Reticulon
• UniProt Gene Name: RTN2
• UniProt Synonym Gene Names: NSPL1; NSP-like protein 1; NSP-like protein I; NSPLI
• UniProt Entry Name: RTN2_HUMAN

NCBI Description

This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]

Uniprot Description

RTN2: Defects in RTN2 are the cause of spastic paraplegia autosomal dominant type 12 (SPG12). A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: endoplasmic reticulum; T-tubule; integral to endoplasmic reticulum membrane

Molecular Function: protein binding

Biological Process: intracellular protein transport across a membrane; regulation of glucose import

Disease: Spastic Paraplegia 12, Autosomal Dominant