Mouse CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Monoclonal Antibody | anti-CFTR antibody

CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)

Cat. Num. AAA62919

• Gene Names: CFTR; CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1
• Reactivity: Human, Mouse. Others not known.
• Applications: Immunohistochemistry, Western Blot, Immunofluorescence
• Synonyms: CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), Antibody; CFTR (Cystic Fibrosis Transmembrane Conductance Regulator); ABC35; ATP Binding Cassette Superfamily C Member 7 (ABCC7); cAMP-dependent chloride channel; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic Fibrosis Transmembrane Conductance Regulator; MRP7; TNR CFTR; anti-CFTR antibody

• Host: Mouse
• Reactivity: Human, Mouse. Others not known.
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: rCFTR/1342
• Specificity: Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3', 5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 1480

• Applicable Applications for anti-CFTR antibody: IHC (Immunohistochemistry), WB (Western Blot), IF (Immunofluorescence)
• Immunogen: Recombinant full-length human CFTR protein
• Cellular Localization: Cell Surface and Cytoplasmic
• Hu-chromosome Location: 7q31.2
• Positive Control: MOLT-4 cells.Pancreas, Kidney or Placenta.
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis of Purified CFTR Mouse Recombinant Monoclonal Antibody (rCFTR/1342).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded Human Pancreas stained with CFTR Mouse Recombinant Monoclonal Antibody (rCFTR/1342).)

References

Riordan, J.R., et al. 1989. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073.

NCBI and Uniprot Product Information

• NCBI GI #: 90421313
• NCBI GeneID: 1080
• NCBI Accession #: NP_000483.3
• NCBI GenBank Nucleotide #: NM_000492.3
• UniProt Accession #: P13569; Q20BG8; Q20BH2; Q2I0A1; Q2I102
• Molecular Weight: 165-170kDa
• NCBI Official Full Name: cystic fibrosis transmembrane conductance regulator
• NCBI Official Synonym Full Names: cystic fibrosis transmembrane conductance regulator
• NCBI Official Symbol: CFTR
• NCBI Official Synonym Symbols: CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1
• NCBI Protein Information: cystic fibrosis transmembrane conductance regulator
• UniProt Protein Name: Cystic fibrosis transmembrane conductance regulator
• UniProt Gene Name: CFTR
• UniProt Synonym Gene Names: ABCC7; CFTR