Rat Ras-related GTP binding A ELISA Kit | RRAGA elisa kit
Rat Ras-related GTP-binding protein A, RRAGA ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds GTP; member of the subfamily of Ras-homologous GTP binding proteins [RGD, Feb 2006]
Uniprot Description
RRAGA: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF- alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Can occur as a homodimer, or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Belongs to the GTR/RAG GTP-binding protein family.
Protein type: G protein regulator, misc.
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; lysosome; cytoplasm; nucleus
Molecular Function: GTPase activity; GDP binding; protein homodimerization activity; GTP binding; protein heterodimerization activity; phosphoprotein binding
Biological Process: cell death; metabolic process; apoptosis; virus-host interaction; regulation of autophagy; positive regulation of cytolysis; cellular response to starvation; positive regulation of TOR signaling pathway
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Product Notes
The Rat RRAGA rraga (Catalog #AAA9332202) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332202 ELISA Kit recognizes Rat RRAGA. It is sometimes possible for the material contained within the vial of "Ras-related GTP binding A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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