60S ribosomal protein L10 (RPL10) Recombinant Protein | RPL10 recombinant protein

Recombinant Human 60S ribosomal protein L10 (RPL10)

Cat. Num. AAA967433

• Gene Names: RPL10; QM; L10; NOV; AUTSX5; DXS648; MRXS35; DXS648E
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 60S ribosomal protein L10 (RPL10); Recombinant Human 60S ribosomal protein L10 (RPL10); RPL10 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-214, Full length protein
• Sequence: GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS
• Sequence Length: 213

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for RPL10 recombinant protein

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as laminin receptor homolog because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3 UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

NCBI and Uniprot Product Information

• NCBI GI #: 746817426
• NCBI GeneID: 6134
• NCBI Accession #: NP_001243506.2
• NCBI GenBank Nucleotide #: NM_001256577.2
• UniProt Accession #: P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5; A3KQT0; D3DWW6
• Molecular Weight: 24,604 Da
• NCBI Official Full Name: 60S ribosomal protein L10 isoform b
• NCBI Official Synonym Full Names: ribosomal protein L10
• NCBI Official Symbol: RPL10
• NCBI Official Synonym Symbols: QM; L10; NOV; AUTSX5; DXS648; MRXS35; DXS648E
• NCBI Protein Information: 60S ribosomal protein L10
• UniProt Protein Name: 60S ribosomal protein L10
• Protein Family: 60S ribosomal protein
• UniProt Gene Name: RPL10

NCBI Description

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Description

Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).