Uniprot Description
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Product Notes
The Rpa2 rpa2 (Catalog #
AAA1407602) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-270, full length protein. The amino acid sequence is listed below: MWNSGFESFT SSTYGGRGGY TQSPGGFGSP TPSQAEKKSR VRAQHIVPCT ISQLLSATLT DEVFRIGDVE ISQVTIVGII RHAEKAPTNI VYKIDDMTAP PMDVRQWVDT DDASGENAVV PPETYVKVAG HLRSFQNKKS LVAFKIIPLE DMNEFTAHIL EVVNSHMMLS KPNSQASAGR PSMSNPGMSE SFNFSGNNFM PANRLTVVQN QVLNLIKACP RPEGLNFQDL RSQLQHMPVP SIKQAVDFLC NEGHIYSTVD DDHFKSTDAE.
It is sometimes possible for the material contained within the vial of
"Replication protein A 32 kDa subunit (Rpa2), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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purchaser may be intending to use a product outside of our accepted criteria.
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responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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