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Replication protein A 32 kDa subunit (Rpa2) Recombinant Protein | Rpa2 recombinant protein

Recombinant Mouse Replication protein A 32 kDa subunit (Rpa2)

Gene Names
Rpa2; RPA34; Rf-A2; AA409079; AI325195; AU020965
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Replication protein A 32 kDa subunit (Rpa2); Recombinant Mouse Replication protein A 32 kDa subunit (Rpa2); Rpa2 recombinant protein
Ordering
 
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For Research Use Only!
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-270, full length protein
Sequence
MWNSGFESFTSSTYGGRGGYTQSPGGFGSPTPSQAEKKSRVRAQHIVPCTISQLLSATLTDEVFRIGDVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAPPMDVRQWVDTDDASGENAVVPPETYVKVAGHLRSFQNKKSLVAFKIIPLEDMNEFTAHILEVVNSHMMLSKPNSQASAGRPSMSNPGMSESFNFSGNNFMPANRLTVVQNQVLNLIKACPRPEGLNFQDLRSQLQHMPVPSIKQAVDFLCNEGHIYSTVDDDHFKSTDAE
Sequence Length
270
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
29,718 Da
NCBI Official Full Name
Replication protein A 32 kDa subunit
NCBI Official Synonym Full Names
replication protein A2
NCBI Official Symbol
Rpa2
NCBI Official Synonym Symbols
RPA34; Rf-A2; AA409079; AI325195; AU020965
NCBI Protein Information
replication protein A 32 kDa subunit
UniProt Protein Name
Replication protein A 32 kDa subunit
Protein Family
UniProt Gene Name
Rpa2
UniProt Synonym Gene Names
Rpa34; RP-A p32; RF-A protein 2; RP-A p34

Uniprot Description

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

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Product Notes

The Rpa2 rpa2 (Catalog #AAA1407602) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-270, full length protein. The amino acid sequence is listed below: MWNSGFESFT SSTYGGRGGY TQSPGGFGSP TPSQAEKKSR VRAQHIVPCT ISQLLSATLT DEVFRIGDVE ISQVTIVGII RHAEKAPTNI VYKIDDMTAP PMDVRQWVDT DDASGENAVV PPETYVKVAG HLRSFQNKKS LVAFKIIPLE DMNEFTAHIL EVVNSHMMLS KPNSQASAGR PSMSNPGMSE SFNFSGNNFM PANRLTVVQN QVLNLIKACP RPEGLNFQDL RSQLQHMPVP SIKQAVDFLC NEGHIYSTVD DDHFKSTDAE. It is sometimes possible for the material contained within the vial of "Replication protein A 32 kDa subunit (Rpa2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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