ROR1 recombinant protein

Recombinant Human ROR1 Protein (C-Fc)

Cat. Num. AAA2557257

• Gene Names: ROR1; NTRKR1; dJ537F10.1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: ROR1; Recombinant Human ROR1 Protein (C-Fc); IL17Rinterleukin-17 receptor A; interleukin 17 receptor A; IL17RA; CD217; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase; ROR1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Gln30-Glu403
• Sequence Length: 937

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for ROR1 recombinant protein

Protein Construction: Recombinant Human ROR1 is produced by our mammalian expression system and the target gene encoding Gln30-Glu403 is expressed with a Fc tag at the C-terminus.

Background: CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK, and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 118572711
• NCBI GeneID: 4919
• UniProt Accession #: Q01973
• Molecular Weight: Molecular Mass: 68.9kDa; Actual Protein Molecular Mass: 90-110kDa
• NCBI Official Full Name: Inactive tyrosine-protein kinase transmembrane receptor ROR1
• NCBI Official Synonym Full Names: receptor tyrosine kinase like orphan receptor 1
• NCBI Official Symbol: ROR1
• NCBI Official Synonym Symbols: NTRKR1; dJ537F10.1
• NCBI Protein Information: inactive tyrosine-protein kinase transmembrane receptor ROR1
• UniProt Protein Name: Tyrosine-protein kinase transmembrane receptor ROR1
• Protein Family: Inactive tyrosine-protein kinase transmembrane receptor
• UniProt Gene Name: ROR1
• UniProt Synonym Gene Names: NTRKR1
• UniProt Entry Name: ROR1_HUMAN

NCBI Description

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Uniprot Description

ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Ror family

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function: Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway