ROR1 recombinant protein

Human ROR1, soluble

Cat. Num. AAA692485

• Gene Names: ROR1; NTRKR1; dJ537F10.1
• Reactivity: Human
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Synonyms: ROR1; Human ROR1; soluble; NTRKR1; Neurotrophic tyrosine kinase; receptor-related 1; Tyrosine-protein kinase; transmembrane receptor ROR1; Receptor-tyrosine-kinase-like orphan receptor 2; ROR1 recombinant protein

• Host: CHO cells
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: QETELSVSAE LVPTSSWNIS SELNKDSYLT LDEPMNNITT SLGQTA ELHC KVSGNPPPTI RWFKNDAPVV QEPRRLSFRS TIYGSRLRIR N LDTTDTGYF QCVATNGKEV VSSTGVLFVK FGPPPTASPG YSDEYEE DGF CQPYRGIACA RFIGNRTVYM ESLHMQGEIE NQITAAFTMI GT SSHLSDKC SQFAIPSLCH YAFPYCDETS SVPKPRDLCR DECEILEN VL CQTEYIFARS NPMILMRLKL PNCEDLPQPE SPEAANCIRI GIP MADPINK NHKCYNSTGV DYRGTVSVTK SGRQCQPWNS QYPHTHTFT A LRFPELNGGH SYCRNPGNQK EAPWCFTLDE NFKSDLCDIP ACDS KDSKEK NKMEILY
• Sequence Length: 393

Related Product Information for ROR1 recombinant protein

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtual absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature B-cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: most notably, but not exclusively, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an œorphan receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain. Recombinant Human ROR1 is a glycoprotein containing 377 amino acid residues, and has a calculated molecular weight of approximately 42.4 kDa. As a result of glycosylation, Recombinant Human ROR1 migrates with an apparent molecular mass of approximately 55-65 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.

Product Categories/Family for ROR1 recombinant protein

Soluble receptors

NCBI and Uniprot Product Information

• NCBI GI #: 134152686
• NCBI GeneID: 4919
• NCBI Accession #: NP_001077061.1
• NCBI GenBank Nucleotide #: NM_001083592.1
• UniProt Accession #: Q01973; Q5VVX6; Q66K77; Q92776
• Molecular Weight: 43,826 Da
• NCBI Official Full Name: inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2
• NCBI Official Synonym Full Names: receptor tyrosine kinase like orphan receptor 1
• NCBI Official Symbol: ROR1
• NCBI Official Synonym Symbols: NTRKR1; dJ537F10.1
• NCBI Protein Information: inactive tyrosine-protein kinase transmembrane receptor ROR1
• UniProt Protein Name: Inactive tyrosine-protein kinase transmembrane receptor ROR1
• Protein Family: Inactive tyrosine-protein kinase transmembrane receptor
• UniProt Gene Name: ROR1
• UniProt Synonym Gene Names: NTRKR1

NCBI Description

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Uniprot Description

ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding