Rabbit Rho-associated, coiled-coil containing protein kinase 1 ELISA Kit | ROCK1 elisa kit
Rabbit Rho-associated protein kinase 1, ROCK1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization 1 PublicationManual assertion based on experiment in:Ref.2
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor: Magnesium
Enzyme regulation: Activated by RHOA binding. Inhibited by Y-27632
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Product Notes
The Rabbit ROCK1 rock1 (Catalog #AAA9327285) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327285 ELISA Kit recognizes Rabbit ROCK1. It is sometimes possible for the material contained within the vial of "Rho-associated, coiled-coil containing protein kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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