RNLS recombinant protein

Recombinant Human RNLS protein

Cat. Num. AAA1561281

• Gene Names: RNLS; C10orf59; RENALASE
• Purity: >90% as determined by SDS-PAGE
• Synonyms: RNLS; Recombinant Human RNLS protein; Renalase; Monoamine oxidase-C; MAO-C; RNLS recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human RNLS (Met1-Ile342) was fused with SUMO tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for RNLS recombinant protein

Catalyzes the oxidation of the less abundant 1, 2-dihydro-beta-NAD(P) and 1, 6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Product Categories/Family for RNLS recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 237649117
• NCBI GeneID: 55328
• NCBI Accession #: NP_001026879.2
• NCBI GenBank Nucleotide #: NM_001031709.2
• UniProt Accession #: Q5VYX0; Q9BS33; Q9NUP8
• Molecular Weight: 37,847 Da
• NCBI Official Full Name: renalase isoform 1
• NCBI Official Synonym Full Names: renalase, FAD-dependent amine oxidase
• NCBI Official Symbol: RNLS
• NCBI Official Synonym Symbols: C10orf59; RENALASE
• NCBI Protein Information: renalase; MAO-C; monoamine oxidase-C; alpha-NAD(P)H oxidase/anomerase
• UniProt Protein Name: Renalase
• UniProt Gene Name: RNLS
• UniProt Synonym Gene Names: C10orf59; MAO-C
• UniProt Entry Name: RNLS_HUMAN

NCBI Description

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

Uniprot Description

RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Secreted; Secreted, signal peptide; EC 1.6.3.5

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: extracellular space

Molecular Function: oxidoreductase activity

Biological Process: heart contraction; regulation of systemic arterial blood pressure; epinephrine metabolic process; phosphate ion homeostasis; norepinephrine metabolic process; dopamine metabolic process