Renalase Recombinant Protein | RNLS recombinant protein

Recombinant Renalase (RNLS)

Cat. Num. AAA2034212

• Gene Names: RNLS; C10orf59; RENALASE
• Reactivity: Human
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >90%
• Synonyms: Renalase; Recombinant Renalase (RNLS); MAO-C; C10orf59; FAD-Dependent Amine Oxidase; Monoamine oxidase-C; alpha-NAD(P)H oxidase/anomerase; RNLS recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: >90%
• Sequence Length: 342

• Applicable Applications for RNLS recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Ala18~Cys180
• Tag: Two N-terminal Tags, His-tag and T7-tag
• Expression System: Prokaryotic Expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 237649117
• NCBI GeneID: 55328
• NCBI Accession #: NP_001026879.2
• NCBI GenBank Nucleotide #: NM_001031709.2
• Molecular Weight: 48.3kDa
• NCBI Official Full Name: renalase isoform 1
• NCBI Official Synonym Full Names: renalase, FAD-dependent amine oxidase
• NCBI Official Symbol: RNLS
• NCBI Official Synonym Symbols: C10orf59; RENALASE
• NCBI Protein Information: renalase
• UniProt Protein Name: Renalase
• Protein Family: Renalase
• UniProt Gene Name: RNLS
• UniProt Synonym Gene Names: C10orf59; MAO-C
• UniProt Entry Name: RNLS_HUMAN

NCBI Description

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

Uniprot Description

RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; EC 1.6.3.5; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: extracellular space

Molecular Function: oxidoreductase activity