Human ring finger protein 40 ELISA Kit | RNF40 elisa kit

Human E3 ubiquitin-protein ligase BRE1B, RNF40 ELISA Kit

Cat. Num. AAA9335815

• Gene Names: RNF40; BRE1B; RBP95; STARING
• Reactivity: Human
• Synonyms: ring finger protein 40; Human E3 ubiquitin-protein ligase BRE1B; RNF40 ELISA Kit; Human E3 ubiquitin-protein ligase BRE1B (RNF40) ELISA kit; BRE1B; DKFZp686K191; KIAA0661; MGC13051; RBP95; STARING; 95 kDa retinoblastoma protein binding protein; BRE1 E3 ubiquitin ligase homolog B; Rb-associated protein; RNF40 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 333440440
• NCBI GeneID: 9810
• NCBI Accession #: NP_001193962.1
• NCBI GenBank Nucleotide #: NM_001207033.1
• UniProt Accession #: O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82
• Molecular Weight: 113,650 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase BRE1B isoform 2
• NCBI Official Synonym Full Names: ring finger protein 40, E3 ubiquitin protein ligase
• NCBI Official Symbol: RNF40
• NCBI Official Synonym Symbols: BRE1B; RBP95; STARING
• NCBI Protein Information: E3 ubiquitin-protein ligase BRE1B; BRE1-B; Rb-associated protein; BRE1 E3 ubiquitin ligase homolog B; 95 kDa retinoblastoma-associated protein; 95 kDa retinoblastoma protein binding protein
• UniProt Protein Name: E3 ubiquitin-protein ligase BRE1B
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF40
• UniProt Synonym Gene Names: BRE1B; KIAA0661; BRE1-B; RBP95
• UniProt Entry Name: BRE1B_HUMAN

NCBI Description

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Uniprot Description

RNF40: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC. Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. Belongs to the BRE1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; EC 6.3.2.-; Ligase; EC 6.3.2.19; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16p11.2-p11.1

Cellular Component: nucleoplasm; neuron projection; membrane; nucleus; ubiquitin ligase complex

Molecular Function: protein binding; protein homodimerization activity; mRNA 3'-UTR binding; zinc ion binding; ubiquitin protein ligase binding; protein complex binding; ubiquitin-protein ligase activity; syntaxin-1 binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; histone monoubiquitination; regulation of mitotic cell cycle; histone H2B ubiquitination