E3 ubiquitin-protein ligase RING2 (RNF2) Recombinant Protein | RNF2 recombinant protein
Recombinant Pongo abelii E3 ubiquitin-protein ligase RING2 (RNF2)
NCBI and Uniprot Product Information
Uniprot Description
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers. Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.
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Product Notes
The RNF2 rnf2 (Catalog #AAA1435012) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-336, Full length protein. The amino acid sequence is listed below: SQAVQTNGTQ PLSKTWELSL YELQRTPQEA ITDGLEIVVS PRSLHSELMC PICLDMLKNT MTTKECLHRF CADCIITALR SGNKECPTCR KKLVSKRSLR PDPNFDALIS KIYPSRDEYE AHQERVLARI NKHNNQQALS HSIEEGLKIQ AMNRLQRGKK QQIENGSGAE DNGDSSHCSN ASTHSNQEAG PSNKRTKTSD DSGLEPDNNN AAMAIDPVMD GASEIELVFR PHPTLMEKDD SAQTRYIKTS GNATVDHLSK YLAVRLALEE LRSKGESNQM NLDTASEKQY TIYIATASGQ FTVLNGSFSL ELVSEKYWKV NKPMELYYAP TKEHK. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase RING2 (RNF2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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