Human ring finger protein 169 ELISA Kit | RNF169 elisa kit

Human RING finger protein 169, RNF169 ELISA Kit

Cat. Num. AAA9331589

• Reactivity: Human
• Synonyms: ring finger protein 169; Human RING finger protein 169; RNF169 ELISA Kit; Human RING finger protein 169 (RNF169) ELISA kit; KIAA1991; ; RNF169 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 148839382
• NCBI GeneID: 254225
• NCBI Accession #: NP_001092108.1
• NCBI GenBank Nucleotide #: NM_001098638.1
• UniProt Accession #: Q8NCN4; Q6N015
• Molecular Weight: 77,194 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF169
• NCBI Official Synonym Full Names: ring finger protein 169
• NCBI Official Symbol: RNF169
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF169
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF169
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF169
• UniProt Synonym Gene Names: KIAA1991
• UniProt Entry Name: RN169_HUMAN

Uniprot Description

RNF169: Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair. Belongs to the RNF169 family.

Protein type: EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: nucleoplasm; nucleus

Molecular Function: zinc ion binding; nucleosome binding; ligase activity

Biological Process: protein ubiquitination; response to DNA damage stimulus