E3 ubiquitin-protein ligase RNF138 (RNF138) Recombinant Protein | RNF138 recombinant protein

Recombinant Human E3 ubiquitin-protein ligase RNF138 (RNF138)

Cat. Num. AAA1363907

• Gene Names: RNF138; NARF; HSD-4; STRIN; hNARF
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase RNF138 (RNF138); Recombinant Human E3 ubiquitin-protein ligase RNF138 (RNF138); RNF138 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-245, Full length protein
• Sequence: AEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
• Sequence Length: 244

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for RNF138 recombinant protein

This protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

NCBI and Uniprot Product Information

• NCBI GI #: 395455059
• NCBI GeneID: 51444
• NCBI Accession #: NP_001178253.2
• NCBI GenBank Nucleotide #: NM_001191324.1
• UniProt Accession #: Q8WVD3; Q9H8K2; Q9UF87; Q9UKI6; B2RE17
• Molecular Weight: 17,262 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF138 isoform 1
• NCBI Official Synonym Full Names: ring finger protein 138
• NCBI Official Symbol: RNF138
• NCBI Official Synonym Symbols: NARF; HSD-4; STRIN; hNARF
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF138
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF138
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF138
• UniProt Synonym Gene Names: hNARF

NCBI Description

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).