Human ring finger protein 135 ELISA Kit | RNF135 elisa kit
Human E3 ubiquitin-protein ligase RNF135, RNF135 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
RNF135: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. Defects in RNF135 are the cause of macrocephaly macrosomia facial dysmorphism syndrome (MMFD). MMFD is an autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Calcium-binding; EC 6.3.2.-; Ubiquitin ligase; DNA replication; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytoplasm; cytosol
Molecular Function: ribonucleoprotein binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: positive regulation of interferon-beta production; innate immune response; protein ubiquitination; negative regulation of interferon type I production; regulation of innate immune response
Disease: Macrocephaly, Macrosomia, Facial Dysmorphism Syndrome
Research Articles on RNF135
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Product Notes
The Human RNF135 rnf135 (Catalog #AAA9327309) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327309 ELISA Kit recognizes Human RNF135. It is sometimes possible for the material contained within the vial of "ring finger protein 135, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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