Human ring finger protein 128 ELISA Kit | RNF128 elisa kit
Human E3 ubiquitin-protein ligase RNF128, RNF128 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
RNF128: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Membrane protein, integral; EC 6.3.2.-
Chromosomal Location of Human Ortholog: Xq22.3
Cellular Component: Golgi apparatus; cytoskeleton; perinuclear region of cytoplasm; endoplasmic reticulum; late endosome; integral to membrane
Molecular Function: zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: protein ubiquitination; negative regulation of cytokine biosynthetic process
Research Articles on RNF128
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Product Notes
The Human RNF128 rnf128 (Catalog #AAA9321055) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321055 ELISA Kit recognizes Human RNF128. It is sometimes possible for the material contained within the vial of "ring finger protein 128, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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