Relaxin 3 Recombinant Protein | RLN3 recombinant protein

Relaxin 3 protein

Cat. Num. AAA539391

• Gene Names: RLN3; H3; RXN3; ZINS4; insl7
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: Relaxin 3; Relaxin 3 protein; Relaxin-3 protein; INSL7 protein; Relaxin-3; H3 relaxin protein; Insulin-like peptide-7 protein; RLN3 recombinant protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Supplied as a lyophilized powder.
• Sequence: Region of Relaxin 3 protein corresponding to amino acids (A-chain): DVLAGLSSS CCKWGCSKSE ISSLC and (B-chain): RAAPYGVRL CGREFIRAVI FTCGGSRW
• Sequence Length: 142

• Applicable Applications for RLN3 recombinant protein: User optimized
• Protein Type: Recombinant
• Biological Significance: Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as ?somatostatin-like? or ?angiotensin-like? peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an ?orphan? G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for RLN3 recombinant protein

Purified recombinant Human Relaxin 3 protein

Product Categories/Family for RLN3 recombinant protein

Hormones & Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 18254464
• NCBI GeneID: 117579
• NCBI Accession #: NP_543140.1
• NCBI GenBank Nucleotide #: NM_080864.2
• UniProt Accession #: Q8WXF3; Q6UXW5
• Molecular Weight: 5.5 kDa
• NCBI Official Full Name: relaxin-3 preproprotein
• NCBI Official Synonym Full Names: relaxin 3
• NCBI Official Symbol: RLN3
• NCBI Official Synonym Symbols: H3; RXN3; ZINS4; insl7
• NCBI Protein Information: relaxin-3
• UniProt Protein Name: Relaxin-3
• Protein Family: Relaxin
• UniProt Gene Name: RLN3
• UniProt Synonym Gene Names: INSL7; RXN3; ZINS4; Insulin-like peptide 7
• UniProt Entry Name: REL3_HUMAN

NCBI Description

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes. [provided by RefSeq, Jul 2008]

Uniprot Description

RLN3: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). Belongs to the insulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular region

Molecular Function: protein binding; G-protein-coupled receptor binding; hormone activity