E3 ubiquitin-protein ligase RLIM (Rlim) Recombinant Protein | Rlim recombinant protein

Recombinant Mouse E3 ubiquitin-protein ligase RLIM (Rlim)

Cat. Num. AAA1355366

• Gene Names: Rlim; Ha1r; Rlim1; Rnf12; AL022832; AW743871
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase RLIM (Rlim); Recombinant Mouse E3 ubiquitin-protein ligase RLIM (Rlim); Rlim recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-600, Full length protein
• Sequence: MENSDSNDKGSDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTEEELLRRLQQIKEGPPPQSPDENRAGESSDDVTNSDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQTSENESEPSTRRLSVENMESSSQRQMENSASESASARPSRAERNSAEAVTEVPTTRAQRRARSRSPEHRRTRARAERSRSPLQPTSEIPRRAPTLEQSSENEPEGSSRTRHHVTLRQQISGPELLGRGLFAASGSRNPSQGTSSSDTGSNSESSGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQAPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPSASVSSRNVERVESRNGRGSSGGGNSSGSSSSSSPSPSSSGESSESSSEMFEGSSEGGSSGPSRRDGRHRAPVTFDESGSLPFLSLAQFFLLNEDDEDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLSSGNRESVV
• Sequence Length: 600

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Rlim recombinant protein

This protein is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1
CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1
LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 47078289
• NCBI GeneID: 19820
• NCBI Accession #: NP_035406.3
• NCBI GenBank Nucleotide #: NM_011276.4
• UniProt Accession #: Q9WTV7; Q8CE02; Q91X19; Q9CYY2
• Molecular Weight: 66,377 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RLIM
• NCBI Official Synonym Full Names: ring finger protein, LIM domain interacting
• NCBI Official Symbol: Rlim
• NCBI Official Synonym Symbols: Ha1r; Rlim1; Rnf12; AL022832; AW743871
• NCBI Protein Information: E3 ubiquitin-protein ligase RLIM
• UniProt Protein Name: E3 ubiquitin-protein ligase RLIM
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: Rlim
• UniProt Synonym Gene Names: Rnf12; R-LIM

Uniprot Description

E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.