Ras and Rab interactor 2 (RIN2) Recombinant Protein | RIN2 recombinant protein

Recombinant Human Ras and Rab interactor 2 (RIN2) , partial

• Gene Names: RIN2; MACS; RASSF4
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ras and Rab interactor 2 (RIN2); Recombinant Human Ras and Rab interactor 2 (RIN2); partial; RIN2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 944

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for RIN2 recombinant protein

The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. This protein binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family.

NCBI and Uniprot Product Information

• NCBI GI #: 336088636
• NCBI GeneID: 54453
• NCBI Accession #: NP_001229510.1
• NCBI GenBank Nucleotide #: NM_001242581.1
• UniProt Accession #: Q8WYP3; Q00425; Q5TFT8; Q9BQL3; Q9H071
• Molecular Weight: 105,613 Da
• NCBI Official Full Name: ras and Rab interactor 2 isoform 1
• NCBI Official Synonym Full Names: Ras and Rab interactor 2
• NCBI Official Symbol: RIN2
• NCBI Official Synonym Symbols: MACS; RASSF4
• NCBI Protein Information: ras and Rab interactor 2
• UniProt Protein Name: Ras and Rab interactor 2
• Protein Family: Ras and Rab interactor
• UniProt Gene Name: RIN2
• UniProt Synonym Gene Names: RASSF4

NCBI Description

The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Uniprot Description

Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP.