Probable ATP-dependent RNA helicase A (rha-1) Recombinant Protein | rha-1 recombinant protein

Recombinant Caenorhabditis elegans Probable ATP-dependent RNA helicase A (rha-1), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Probable ATP-dependent RNA helicase A (rha-1); Recombinant Caenorhabditis elegans Probable ATP-dependent RNA helicase A (rha-1); partial; rha-1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,301

• Species: Caenorhabditis elegans
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 86562256
• NCBI GeneID: 174417
• NCBI Accession #: NP_495890.2
• NCBI GenBank Nucleotide #: NM_063489.5
• UniProt Accession #: Q22307
• Molecular Weight: 144,214 Da
• NCBI Official Full Name: ATP-dependent RNA helicase A
• NCBI Official Symbol: rha-1
• NCBI Protein Information: ATP-dependent RNA helicase A
• UniProt Protein Name: ATP-dependent RNA helicase A
• Protein Family: Probable ATP-dependent RNA helicase
• UniProt Gene Name: rha-1
• UniProt Synonym Gene Names: NDH II

Uniprot Description

Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replication at origins of replication and cell cycle progression (). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors (PubMed:15817227). Plays several roles in post-transcriptional regulation of gene expression. Promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Plays also a role in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus ().