Human regulator of G-protein signaling 18 ELISA Kit | RGS18 elisa kit

Human Regulator of G-protein signaling 18, RGS18 ELISA Kit

Cat. Num. AAA9324542

• Gene Names: RGS18; RGS13
• Reactivity: Human
• Synonyms: regulator of G-protein signaling 18; Human Regulator of G-protein signaling 18; RGS18 ELISA Kit; Human Regulator of G-protein signaling 18 (RGS18) ELISA kit; RP11-142L4.1; RGS13; regulator of G-protein signalling 13; regulator of G-protein signalling 18; RGS18 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Human serum, plasma or tissue homogenates samples
• Assay Type: Quantitative Sandwich
• Detection Range: 62.5pg/ml-2000pg/ml
• Sensitivity: 10pg/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for RGS18 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of RGS18 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 18640750
• NCBI GeneID: 64407
• NCBI Accession #: NP_570138.1
• NCBI GenBank Nucleotide #: NM_130782.2
• UniProt Accession #: Q9NS28; B2RD23
• Molecular Weight: 27,582 Da
• NCBI Official Full Name: regulator of G-protein signaling 18
• NCBI Official Synonym Full Names: regulator of G-protein signaling 18
• NCBI Official Symbol: RGS18
• NCBI Official Synonym Symbols: RGS13
• NCBI Protein Information: regulator of G-protein signaling 18; regulator of G-protein signalling 13; regulator of G-protein signalling 18
• UniProt Protein Name: Regulator of G-protein signaling 18
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS18
• UniProt Synonym Gene Names: RGS13; RGS18
• UniProt Entry Name: RGS18_HUMAN

NCBI Description

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS18: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha.

Protein type: GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 1q31.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: GTPase activator activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity