Mouse regulatory factor X-associated ankyrin-containing protein ELISA Kit | RFXANK elisa kit
Mouse DNA-binding protein RFXANK, RFXANK ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RFXANK: Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes. Defects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2); also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; intercellular bridge; cytoplasm; intracellular; nucleus
Molecular Function: protein binding; DNA binding; histone deacetylase binding; transcription cofactor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter
Research Articles on RFXANK
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Product Notes
The Mouse RFXANK rfxank (Catalog #AAA9323256) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323256 ELISA Kit recognizes Mouse RFXANK. It is sometimes possible for the material contained within the vial of "regulatory factor X-associated ankyrin-containing protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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