REG1b recombinant protein

Recombinant Human REG1b protein

Gene Names

REG1B; REGH; REGL; PSPS2; REGI-BETA

Purity

>90% as determined by SDS-PAGE

Synonyms

REG1b; Recombinant Human REG1b protein; Lithostathine-1-beta; Pancreatic stone protein 2; PSP-2; Regenerating islet-derived protein 1-beta; REG-1-beta; Regenerating protein I beta; REG1b recombinant protein

Ordering
Cat. Num. AAA1561127 For Research Use Only!

Host

E Coli

Purity/Purification

>90% as determined by SDS-PAGE

Form/Format

Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

Species

Homo sapiens (Human)

Protein Construction

A DNA sequence encoding the human REG1b (Gln23-Asn166) was fused with His tag

Reconstitution

Reconstitute in sterile water for a stock solution.

Preparation and Storage

Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for REG1b recombinant protein

Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreatopathy. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human REG1A, and it is was expressed only in pancreas. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation. The REG1A and REG1B gene and proteins could play different roles in the pancreas.

Product Categories/Family for REG1b recombinant protein

Protein

NCBI and Uniprot Product Information

NCBI GI #

10835248

NCBI GeneID

5968

NCBI Accession #

NP_006498.1

NCBI GenBank Nucleotide #

NM_006507.3

UniProt Accession #

P48304

Molecular Weight

18,665 Da

NCBI Official Full Name

lithostathine-1-beta

NCBI Official Synonym Full Names

regenerating islet-derived 1 beta

NCBI Official Symbol

REG1B

NCBI Official Synonym Symbols

REGH; REGL; PSPS2; REGI-BETA

NCBI Protein Information

lithostathine-1-beta; PSP-2; REG-1-beta; lithostathine 1 beta; pancreatic stone protein 2; regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein); regenerating islet-derived protein 1-beta; regenerating protein I beta; sec

UniProt Protein Name

Lithostathine-1-beta

Protein Family

Lithostathine

UniProt Gene Name

REG1B

UniProt Synonym Gene Names

PSPS2; REGL; PSP-2; REG-1-beta

UniProt Entry Name

REG1B_HUMAN

NCBI Description

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

Uniprot Description

REG1B: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p12

Molecular Function: carbohydrate binding

Biological Process: cell proliferation

Research Articles on REG1b

1. Additional serum biomarkers, particularly SYCN and REG1B, when combined with CA19.9, show promise as improved diagnostic indicators of pancreatic cancer, which therefore warrants further validation.

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Product Notes

The REG1b reg1b (Catalog #AAA1561127) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "REG1b, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.