Interleukin 6 Active Protein | Il6 active protein

Interleukin 6, Recombinant, Mouse (IL-6)

Cat. Num. AAA650167

• Gene Names: Il6; ILg6; Ifnb2
• Purity: Highly Purified; 96% by SDS-PAGE. Chromatographically purified.
• Synonyms: Interleukin 6; Recombinant; Mouse (IL-6); Il6 active protein

• Host: Recombinant, Murine (E Coli)
• Purity/Purification: Highly Purified; 96% by SDS-PAGE. Chromatographically purified.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.4.

• Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells is <0.02ng/ml, cooresponding to a specific activity of 50,000,000 units/mg.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. For long-term storage add 0.1% HSA or BSA, aliquot and store at -20 degree C. Aliquot to avoid repeated freezing and thawing. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for Il6 active protein

Interleukin-6 is a potent pro-inflammatory cytokine primarily produced by activated T cells and an assortment of other cells including endothelial cells and macrophages. IL-6 affects B and T lymphocytes and has been shown to have a role in host defense, acute phase reactions, immune responses and hematopoiesis. Recombinant murine IL-6 is a single, non-glycosylated polypeptide chain containing 187 amino acids.

Product Categories/Family for Il6 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 7549769
• NCBI GeneID: 24498
• NCBI Accession #: NP_036721.1
• NCBI GenBank Nucleotide #: NM_012589.1
• UniProt Accession #: P20607
• Molecular Weight: 21709D
• NCBI Official Full Name: interleukin-6
• NCBI Official Synonym Full Names: interleukin 6
• NCBI Official Symbol: Il6
• NCBI Official Synonym Symbols: ILg6; Ifnb2
• NCBI Protein Information: interleukin-6; IL-6; Interleukin 6 (interferon, beta 2)
• UniProt Protein Name: Interleukin-6
• Protein Family: Interleukin
• UniProt Gene Name: Il6
• UniProt Synonym Gene Names: Il-6
• UniProt Entry Name: IL6_RAT

NCBI Description

a cytokine involved in development and possibly in neurodegenerative processes [RGD]

Uniprot Description

Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-6 superfamily.