Scavenger Receptor A5 Active Protein | Sr-CI active protein
Scavenger Receptor A5, Recombinant, Mouse (SCARA5, Testis Expressed Scavenger Receptor, Tesr)
Gene Names
Sr-CI; CG4099; CT9876; D-SR-CI; DmelCG4099; dScR-I; dSR-C1; dSR-CI; DSR-CI; dSRC-I; Sr-C1; SR-C1; SR-CI; Sr-Cl
Purity
Highly Purified95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.
Synonyms
Scavenger Receptor A5; Recombinant; Mouse (SCARA5; Testis Expressed Scavenger Receptor; Tesr); Sr-CI active protein
Host
Recombinant Mouse
Purity/Purification
Highly Purified
95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.
95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.
Form/Format
Supplied as a lyophilized powder in PBS. Reconstitute with PBS to 100ug/ml.
Activity
Measured by its ability to bind Fluorescein conjugated S. aureus Bioparticles.
Endotoxin Level
1EU/1ug.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile PBS and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Sr-CI active protein
Scavenger receptor A5 (SCARA5; also known as testis expressed scavenger receptor Tesr) is a Class A scavenger receptor that is related to CL-P1, MARCO, SCARA3, and SR-A1. All are type II transmembrane proteins that contain a collagenous stalk (1-3). Mature mouse SCARA5 consists of a 60 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 410 aa C-terminal extracellular domain (ECD) that contains a coiled-coil, a collagen-like, and a scavenger receptor cysteine-rich (SRCR) region (4, 5). Within the ECD, mouse SCARA5 shares 87% and 98% aa sequence identity with human and rat SCARA5, respectively. It shares 24%-29% aa sequence identity with CL-P1, MARCO, SCARA3, and SR-A1. Alternative splicing generates one isoform that lacks the SRCR domain and a second that additionally lacks the cytoplasmic and transmembrane regions. SCARA5 is a cell surface disulfide-linked homotrimer of > 250kD (5). It is highly expressed in testicular Sertoli and germ cells and more weakly in the epithelia of other tissues (4, 5). During mouse development, SCARA5 expression is attenuated in female embryos at the time of sex determination, whereas it is maintained in the developing testis (4). SCARA5 is re-expressed in the adult ovary (4). SCARA5 binds heat-killed bacterial particles but not yeast particles or modified LDL (5).
A DNA sequence encoding the extracellular domain of mouse SCARA5 (Arg 83-Pro 491; Accession # Q8K299) was fused with a 6x histidine tag at the N-terminus and expressed in Chinese Hamster Ovary cells.
Calculated molecular mass of 45.5kD. As a result of glycosylation, the recombinant protein migrates as an ~ 60-90kD protein in SDS-PAGE under reducing conditions.
A DNA sequence encoding the extracellular domain of mouse SCARA5 (Arg 83-Pro 491; Accession # Q8K299) was fused with a 6x histidine tag at the N-terminus and expressed in Chinese Hamster Ovary cells.
Calculated molecular mass of 45.5kD. As a result of glycosylation, the recombinant protein migrates as an ~ 60-90kD protein in SDS-PAGE under reducing conditions.
Product Categories/Family for Sr-CI active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
69,916 Da
NCBI Official Full Name
scavenger receptor class C, type I
NCBI Official Synonym Full Names
Scavenger receptor class C, type I
NCBI Official Symbol
Sr-CI
NCBI Official Synonym Symbols
CG4099; CT9876; D-SR-CI; DmelCG4099; dScR-I; dSR-C1; dSR-CI; DSR-CI; dSRC-I; Sr-C1; SR-C1; SR-CI; Sr-Cl
NCBI Protein Information
CG4099 gene product from transcript CG4099-RA; CG4099-PA; Sr-CI-PA; scavenger receptor; scavenger receptor C, type I; scavenger receptor class C, type 1; scavenger receptor class C, type I
UniProt Protein Name
SR-CI
UniProt Gene Name
Sr-CI
UniProt Synonym Gene Names
SR-CI
UniProt Entry Name
Q9V3H7_DROME
Research Articles on Sr-CI
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Product Notes
The Sr-CI sr-ci (Catalog #AAA636135) is an Active Protein produced from Recombinant Mouse and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Scavenger Receptor A5, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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